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When a space ship leaves the earth and returns, care is taken to build the space craft in a sterilized room. But then, it is not possible to completely rid it of all microbes.
In an experiment, salmonella germs were found to be deadlier when they came back from space.
http://hosted.ap.org/dynamic/stories/G/GERMS_IN_SPACE?SITE=DCUSN&SECTION=HOME&TEMPLATE=DEFAULT
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